Biochem/physiol Actions

Reversible: yes

Primary TargetCaM kinase II

Cell permeable: yes

General description

A water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Tombes, R.M., et al. 1995. Cell Growth Differ.6, 1063.Chen, C., et al. 1994. Science266, 291.Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Packaging

500 µg in Glass bottle

Packaged under inert gas

Physical form

A 5 mM (500 µg/167 µL) sterile-filtered solution of KN-93 Phosphate (Cat. No. 422711) in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)